News & Publications

October 2022

Resistor: An algorithm for predicting resistance mutations via Pareto optimization over multistate protein design and mutational signatures

April 2021

mTORC2 controls the activity of PKC and Akt by phosphorylating a conserved TOR interaction motif

March 2020

Allosteric Kinase Inhibitors Reshape MEK1 Kinase Activity Conformations in Cells and In Silico

November 2020

Mutation-oriented profiling of autoinhibitory kinase conformations predicts RAF inhibitor efficacies

February 2020

KinCon: Cell‐based recording of full‐length kinase conformations

August 2019

BRAF inhibitors promote intermediate BRAF(V600E) conformations and binary interactions with activated RAS

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November 15, 2022

Resistor: An algorithm for predicting resistance mutations via Pareto optimization over multistate protein design and mutational signatures

September 27, 2022

mTORC2 controls the activity of PKC and Akt by phosphorylating a conserved TOR interaction motif

September 27, 2022

Allosteric Kinase Inhibitors Reshape MEK1 Kinase Activity Conformations in Cells and In Silico

September 27, 2022

Mutation-oriented profiling of autoinhibitory kinase conformations predicts RAF inhibitor efficacies

September 27, 2022

KinCon: Cell‐based recording of full‐length kinase conformations

September 27, 2022

BRAF inhibitors promote intermediate BRAF(V600E) conformations and binary interactions with activated RAS